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It appears that the N-terminal domain of BCR can cause oligomerization of the BCR-ABL1 protein product, thus activating the ABL1 tyrosine kinase domain of the fusion protein (6, 10, 11).
It appears that the N-terminal domain of BCR can cause oligomerization of the BCR-ABL1 protein product, thus activating the ABL1 tyrosine kinase domain of the fusion protein (6, 10, 11).
See the '''[http://www.ccga.io/index.php/BCR "ABL1 gene"]''' for additional details of the BCR-ABL1 gene fusion.
==Common Alteration Types==
==Common Alteration Types==