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==Primary Author(s)*==
==Primary Author(s)*==
Kay Weng Choy MBBS
Kay Weng Choy, MBBS, Monash Medical Centre
__TOC__
__TOC__
==Cancer Category/Type==
==Cancer Category/Type==
Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), chronic myeloid leukemia (CML)
*'''[http://www.ccga.io/index.php/Myeloid_Neoplasms_with_Germline_Predisposition Myeloid Neoplasms with Germline Predisposition]'''
--- '''[http://www.ccga.io/index.php/HAEM4:Myeloid_Neoplasms_with_Germline_GATA2_Mutation Myeloid Neoplasms with Germline GATA2 Mutation]'''
Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)
Chronic myeloid leukemia (CML)
Non-small cell lung cancer (NSCLC)
Non-small cell lung cancer (NSCLC)
According to the Catalogue of Somatic Mutations in Cancer (COSMIC), c.490G>A (NM_032638.4) (p.Ala164Thr) and c.15C>G (NM_032638.4) (p.Pro5Pro) have been observed in 49 and 96 cases, respectively, predominantly in the setting of acute myeloid leukemia (https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=GATA2, Accessed 1st August 2018)
According to the Catalogue of Somatic Mutations in Cancer (COSMIC), c.490G>A (NM_032638.4) (p.Ala164Thr) and c.15C>G (NM_032638.4) (p.Pro5Pro) have been observed in 49 and 96 cases, respectively, predominantly in the setting of acute myeloid leukemia (https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=GATA2, Accessed 1st August 2018)
==Internal Pages==
'''[[HAEM5:Acute myeloid leukaemia with MECOM rearrangement]]'''
'''[[HAEM4:Myeloid Neoplasms with Germline GATA2 Mutation]]'''
==External Links==
==External Links==
'''[http://oncokb.org/#/gene/gata2 ''GATA2'' by OncoKB]''' - mutational landscape, mutation effect, variant classification
'''[http://oncokb.org/#/gene/gata2 ''GATA2'' by OncoKB]''' - mutational landscape, mutation effect, variant classification
'''[https://www.ncbi.nlm.nih.gov/gene/861 ''GATA2'' by NCBI Gene]''' - brief gene overview
'''[https://www.ncbi.nlm.nih.gov/gene/2624 ''GATA2'' by NCBI Gene]''' - brief gene overview
'''[https://www.mycancergenome.org/content/gene/gata2/ ''GATA2'' by My Cancer Genome]''' - brief gene overview
'''[https://www.mycancergenome.org/content/gene/gata2/ ''GATA2'' by My Cancer Genome]''' - brief gene overview
'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=gata2 ''GATA2'' by GeneCards]''' - general gene information and summaries
'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=gata2 ''GATA2'' by GeneCards]''' - general gene information and summaries
'''[http://www.omim.org/entry/151385 ''GATA2'' by OMIM]''' - compendium of human genes and genetic phenotypes
'''[http://www.omim.org/entry/137295 ''GATA2'' by OMIM]''' - compendium of human genes and genetic phenotypes
'''[https://databases.lovd.nl/shared/genes/GATA2 ''GATA2'' by LOVD(3)]''' - Leiden Open Variation Database
'''[https://databases.lovd.nl/shared/genes/GATA2 ''GATA2'' by LOVD(3)]''' - Leiden Open Variation Database
'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=GATA2 ''GATA2'' by TICdb]''' - database of Translocation breakpoints In Cancer
'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=GATA2 ''GATA2'' by TICdb]''' - database of Translocation breakpoints In Cancer
12. Kumar MS, et al., (2012). The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. PMID 22541434
12. Kumar MS, et al., (2012). The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. PMID 22541434
== Notes ==
==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
[[Category:Cancer Genes G]]
[[Category:Cancer Genes G]]