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How to Curate a Gene Page (view source)
Revision as of 15:17, 6 December 2018
, 15:17, 6 December 2018→5. GENE OVERVIEW Section
=== 5. GENE OVERVIEW Section ===
=== 5. GENE OVERVIEW Section ===
This is where you will be compelled to find and read journal articles and books text. You may have found some relevant articles listed at some of the EXTERNAL LINKS sites (esp. Uniprot and NCBI Gene), but you will have to search for new, relevant articles in PubMed and also from the Hematological Cancer resource "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf). Note that you will be finding information that will fit in other sections of the gene template, like CANCER CATEGORY TYPE and COMMON ALTERATION TYPES and REFERENCES. This section should describe in 1 paragraph (approx 5-7 sentences):
This is where you will be compelled to find and read journal articles and book text. You may have found some relevant articles listed at some of the EXTERNAL LINKS sites (esp. Uniprot and NCBI Gene), but you will have to search for new, relevant articles in PubMed and also from the Hematological Cancer resource "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf). Note that you will be finding information that will fit in other sections of the gene template, like CANCER CATEGORY TYPE and COMMON ALTERATION TYPES and REFERENCES. This section should describe in 1 paragraph (approx 5-7 sentences):
# the molecular function of the gene/protein
# the molecular function of the gene/protein
# its normal cellular role
# its normal cellular role, for example in cellular processes or cellular pathways.
# its role in diseases, esp. cancer diseases in the CCGA.
# its role in diseases, esp. cancer diseases in the CCGA.
# interesting or frequent mutations and their effects on specific cancers.
# interesting or frequent mutations and their effects on specific cancers.
# role in drug resistance, if any.
# role in drug resistance, if any.
# diagnostic or prognostic value, if any.
A few examples are shown below.
A few examples are shown below.
For molecular information and some disease and mutation information, this section is most informed by reading the EXTERNAL LINKS resources of:
For molecular information and some disease and mutation information, this section is most informed by reading the EXTERNAL LINKS resources of:
# UniProt
# UniProt (by far the best)
# GeneCards
# GeneCards
# NCBI Gene
# NCBI Gene
# OMIM
# OMIM
# WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf)
# WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf)
# Pubmed (search for YFG, esp. in o=context of "cancer" or specific cancers.
# Pubmed (search for YFG, esp. in context of "cancer" or specific cancers)
Note that in this section, you must also go to PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and search for Articles about YGI and cancer or specific cancers. The best articles to read are usually the most recent and are freely available to the public (eg, PubMed Central). If you are new to YGI and some of these cancers, then a recent review article may be helpful. Also very helpful is to search through the book "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues" (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf) for YGI and read those sections where YGI is mentioned.
Note that in this section, you must also go to PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and search for articles about YGI and cancer or specific cancers. The best articles to read are usually the most recent and should be are freely available to the public (eg, PubMed Central). If you are new to YGI and some of these cancers, then a recent review article may be helpful. Also very helpful is to use the book "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues" (download from http://publications.iarc.fr/_publications/media/download/1511/700ac655d7f248cf1044efd985275086ed4f341f.pdf) Search through the PDF file for YGI and read those sections where YGI is mentioned.
We suggest when writing in the wiki, that you use a reference "placeholder" in the text you are writing. For example use the first author's last name and year as a placeholder in the text, at the end of a sentence. Then, write the full reference into the REFERENCE Section (section 9) using the proper syntax suggested for either book, article or internet source. Then, when you are done with all sections and the reference section, you can replace the "placeholders" with the the numbered reference.
We suggest when writing in the wiki, that you use a reference "placeholder" in the text you are writing. For example, use the first author's last name and year as a placeholder in the text, at the end of a sentence. Then, write the full reference into the REFERENCE Section (section 9) using the proper syntax suggested for either book, article or internet source. Then, when you are done with all sections and the reference section, you can replace the "placeholders" with the the numbered reference.
=== 4. CANCER CATEGORY/TYPE Section ===
=== 4. CANCER CATEGORY/TYPE Section ===