Changes

==Synonyms==

==Synonyms==

"KIT Proto-Oncogene Receptor Tyrosine Kinase"; "V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog";  PBT; SCFR; C-Kit; CD117; MASTC

"KIT Proto-Oncogene Receptor Tyrosine Kinase"; "V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog";  PBT; "Stem Cell Factor Receptor"; SCFR; "Cellular KIT"; C-Kit; CD117; MASTC

==Genomic Location==

==Genomic Location==

'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1

'''Cytoband:''' 4q12

'''Genomic Coordinates:'''  

'''Genomic Coordinates:'''  

EXAMPLE: chr17:7,571,720-7,590,868 [hg19]

chr4:55,524,085-55,606,881(GRCh37/hg19)

EXAMPLE: chr17:7,668,402-7,687,538 [hg38]

 

[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]

 

==Gene Overview==

==Gene Overview==

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. ([https://www.uniprot.org/uniprot/P10721 adapted from UniProt Description]).

This gene encodes the human homolog of the proto-oncogene c-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.  Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. ([https://www.uniprot.org/uniprot/P10721 adapted from UniProt Description]).

==Common Alteration Types==

==Common Alteration Types==

Put your text here and/or fill in the table with an X where applicable

The most common mutations found in KIT occur in the Tyrosine Kinase domain

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