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KIT (view source)

Revision as of 18:27, 2 August 2018

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==Cancer Category/Type==

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KIT mutations are prevalent in many cancers, including gastrointestinal stromal tumors (90%), genetical tract cancers (22%), haematopoietic and lymphoid cancers (13.8%), Melanomas (7%)

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KIT mutations are prevalent in many cancers, including gastrointestinal stromal tumors (90%)[3], genetical tract cancers (22%), haematopoietic and lymphoid cancers (13.8%), Melanomas (7%) ([https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=kit see COSMIC]).

[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]

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==Common Alteration Types==

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The most common mutations found in KIT occur in the Tyrosine Kinase domain, with the vast majority being at the D816 residue ([https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=kit see COSMIC]).

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Mutaions in Kit are found clustered in the juxtamembrane domain, and the XX doamin and The most common mutations found in KIT occur in the Tyrosine Kinase domain, with the vast majority being at the D816 residue ([https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=kit see COSMIC]).

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