Changes

Mutations of KIT have been shown to have prognostic significance among AML with t(8;21)(q22;q22) (RUNX1-RUNXT1) and inv(16)(p13.1q22)/ t(16;16)(p13.1;q22) (CBFB-MYH11), in which they are associated with a poor prognosis.  These KIT mutations most commonly occur within exon 8 and 17. [1].  KIT mutations occurs primarily in a subset of leukemias containing inv(16) or t(8;21), so-called core factor binding AML. Apart from exon 17 mutations, also internal tandem duplications in exon 11 have been described.

Mutations of KIT have been shown to have prognostic significance among AML with t(8;21)(q22;q22) (RUNX1-RUNXT1) and inv(16)(p13.1q22)/ t(16;16)(p13.1;q22) (CBFB-MYH11), in which they are associated with a poor prognosis.  These KIT mutations most commonly occur within exon 8 and 17. [1].  KIT mutations occurs primarily in a subset of leukemias containing inv(16) or t(8;21), so-called core factor binding AML. Apart from exon 17 mutations, also internal tandem duplications in exon 11 have been described.

Prognosis. Presence of D816V mutation in KIT is a poor prognostic factor [see ].

Prognosis. Presence of D816V mutation in KIT is a poor prognostic factor [[http://atlasgeneticsoncology.org/Genes/KITID127.html see Atlas of Genetics and Cytogenetics in Oncology and Haematology]].

GIST (gastrointestinal stromal tumors)

GIST (gastrointestinal stromal tumors)