Changes

inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by  binding to the transcription factor encoded by RUNX1.  The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, and leading to lowered and altered transcription of myeloid genes normally controlled by CBFbeta and Runx1 transcription factors [2].

The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by  binding to the transcription factor encoded by ''RUNX1''.  The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, leading to lowered and altered transcription of myeloid genes normally controlled by the CBFbeta and Runx1 transcription factors [2].

{| class="wikitable sortable"

{| class="wikitable sortable"

! Copy Number Loss  !! Copy Number Gain  !!  LOH  !!  Loss-of-Function Mutation  !!  Gain-of-Function Mutation  !!  Translocation/Fusion  

! Copy Number Loss  !! Copy Number Gain  !!  LOH  !!  Loss-of-Function Mutation  !!  Gain-of-Function Mutation  !!  Translocation/Fusion  

|-

|-

|  || ||  ||  || ||  X

|  || ||  ||  || X ||  X

|}

|}