| Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22)<ref>Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p132-134.</ref><ref>Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.</ref>. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML)<ref name=":0">{{Cite journal|last=Ja|first=Pulikkan|last2=Lh|first2=Castilla|date=2018|title=Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia|url=https://pubmed.ncbi.nlm.nih.gov/29755956/|language=en|doi=10.3389/fonc.2018.00129|pmc=PMC5932169|pmid=29755956}}</ref>. | | Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22)<ref>Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p132-134.</ref><ref>Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.</ref>. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML)<ref name=":0">{{Cite journal|last=Ja|first=Pulikkan|last2=Lh|first2=Castilla|date=2018|title=Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia|url=https://pubmed.ncbi.nlm.nih.gov/29755956/|language=en|doi=10.3389/fonc.2018.00129|pmc=PMC5932169|pmid=29755956}}</ref>. |