Search results

• HAEM4Backup:Blastic Plasmacytoid Dendritic Cell Neoplasm
  ....gov/pubmed/30350260|journal=Current Hematologic Malignancy Reports|volume=13|issue=6|pages=477–483|doi=10.1007/s11899-018-0489-z|issn=1558-822X|pmid=3 ...et age and shorter median survival<ref name=":5" />. ''RUNX2'', located on chromosome 6p21, is strongly expressed in pDCs and BPDCN cells. The t(6,8) generates m
  17 KB (2,329 words) - 12:35, 3 November 2023
• HAEM4:Blastic Plasmacytoid Dendritic Cell Neoplasm
  ....gov/pubmed/30350260|journal=Current Hematologic Malignancy Reports|volume=13|issue=6|pages=477–483|doi=10.1007/s11899-018-0489-z|issn=1558-822X|pmid=3 ...et age and shorter median survival<ref name=":5" />. ''RUNX2'', located on chromosome 6p21, is strongly expressed in pDCs and BPDCN cells. The t(6,8) generates m
  17 KB (2,369 words) - 13:47, 3 November 2023
• BRST5:Adenoid Cystic Carcinoma
  ...nih.gov/31105427|journal=Breast Cancer: Basic and Clinical Research|volume=13|pages=1178223419842185|doi=10.1177/1178223419842185|issn=1178-2234|pmc=6501 |Fusions involving ''MYB'' with other gene partners or complex structural abnormalities associated with ''MYB'' gene fusion generate more complex karyotypes. Loss
  19 KB (2,737 words) - 13:17, 29 February 2024
• HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy
  ...mphoblastic leukemias. The majority of cases (>80%) fall within the 44-45 chromosome range. However, beyond this, there are three main groups, that although ra ...edscape Article, Drugs & Diseases, Hematology.</ref>. Hypodiploid ALL with chromosome numbers less than 44 is associated with poor prognosis.
  30 KB (4,118 words) - 14:20, 13 December 2023
• HAEM4:Acute Myeloid Leukemia (AML) with BCR-ABL1
  ...ion. The t(9:22)(q34.1;q11.2) results in the formation of the Philadelphia chromosome and the chimeric BCR-ABL1 fusion gene. It is worth noting that the fusion g ...there are only a few cases described where acquisition of the Philadelphia chromosome upon disease relapse or transformation of antecedent myelodysplastic syndro
  18 KB (2,576 words) - 13:45, 3 November 2023
• HAEM4Backup:Anaplastic Large Cell Lymphoma, ALK-Negative
  ...ac|date=2012-09-13|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http ...rst9=Kip|date=2012|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http
  23 KB (3,346 words) - 12:52, 3 November 2023
• HAEM4:Anaplastic Large Cell Lymphoma, ALK-Negative
  ...ac|date=2012-09-13|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http ...rst9=Kip|date=2012|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http
  24 KB (3,388 words) - 16:41, 4 December 2023
• HAEM4Backup:High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)
  .... Jeffrey|date=2015-02|title=B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas ...pical immunophenotype (e.g. diffuse and strong BCL2 expression) or genetic abnormalities (e.g. a complex karyotype) are present<ref name=":0" /><ref name=":4">{{Cit
  17 KB (2,506 words) - 12:47, 3 November 2023
• HAEM5:Blastic plasmacytoid dendritic cell neoplasm
  ....gov/pubmed/30350260|journal=Current Hematologic Malignancy Reports|volume=13|issue=6|pages=477–483|doi=10.1007/s11899-018-0489-z|issn=1558-822X|pmid=3 ...et age and shorter median survival<ref name=":5" />. ''RUNX2'', located on chromosome 6p21, is strongly expressed in pDCs and BPDCN cells. The t(6,8) generates m
  26 KB (3,637 words) - 14:21, 13 December 2023
• HAEM4:High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)
  .... Jeffrey|date=2015-02|title=B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas ...pical immunophenotype (e.g. diffuse and strong BCL2 expression) or genetic abnormalities (e.g. a complex karyotype) are present<ref name=":0" /><ref name=":4">{{Cit
  18 KB (2,549 words) - 16:38, 4 December 2023
• HAEM5:T-prolymphocytic leukaemia
  |These genetic abnormalities serve as diagnostic markers and generally indicate an aggressive disease. T ...frequent changes are deletions in 12p13 and 22q, gains in 8q24 (MYC), and abnormalities in chromosomes 5p, 6, and 17.
  17 KB (2,392 words) - 14:32, 15 May 2024
• HAEM5:ALK-negative anaplastic large cell lymphoma
  ...ac|date=2012-09-13|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http ...rst9=Kip|date=2012|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http
  32 KB (4,584 words) - 14:16, 13 December 2023
• HAEM5:Acute myeloid leukaemia with BCR::ABL1 fusion
  ...ion. The t(9:22)(q34.1;q11.2) results in the formation of the Philadelphia chromosome and the chimeric BCR-ABL1 fusion gene. It is worth noting that the fusion g ...there are only a few cases described where acquisition of the Philadelphia chromosome upon disease relapse or transformation of antecedent myelodysplastic syndro
  26 KB (3,785 words) - 14:16, 13 December 2023
• CNS5:Ganglioglioma
  ...st2=K.|last3=Comair|first3=Y. G.|date=1995-07|title=Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with in ...st2=K.|last3=Comair|first3=Y. G.|date=1995-07|title=Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with in
  23 KB (3,102 words) - 13:55, 25 February 2024
• HAEM4Backup:Waldenstrom Macroglobulinemia
  ....nlm.nih.gov/23474147|journal=Clinical Lymphoma, Myeloma & Leukemia|volume=13|issue=2|pages=244–246|doi=10.1016/j.clml.2013.02.001|issn=2152-2669|pmid= ...s in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical cou
  35 KB (4,909 words) - 12:40, 3 November 2023
• HAEM5:High-grade B-cell lymphoma, NOS
  .... Jeffrey|date=2015-02|title=B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas ...pical immunophenotype (e.g. diffuse and strong BCL2 expression) or genetic abnormalities (e.g. a complex karyotype) are present<ref name=":0" /><ref name=":4">{{Cit
  26 KB (3,680 words) - 14:26, 13 December 2023
• HAEM4Backup:Intravascular Large B-cell Lymphoma
  ...ging. Radiological findings are often non-specific, but frequently include abnormalities if the central nervous system is imaged using MRI, including hyperintense l ...of three cases of IVLBCL and a literature review, Khoury et al<ref name=":13" /> described case reports of breakpoints involving BCL6, CMYC, PAX5, BCL1,
  46 KB (6,456 words) - 12:45, 3 November 2023
• HAEM4:Waldenstrom Macroglobulinemia
  ....nlm.nih.gov/23474147|journal=Clinical Lymphoma, Myeloma & Leukemia|volume=13|issue=2|pages=244–246|doi=10.1016/j.clml.2013.02.001|issn=2152-2669|pmid= ...s in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical cou
  35 KB (4,949 words) - 16:33, 4 December 2023
• HAEM4:Intravascular Large B-cell Lymphoma
  ...ging. Radiological findings are often non-specific, but frequently include abnormalities if the central nervous system is imaged using MRI, including hyperintense l ...of three cases of IVLBCL and a literature review, Khoury et al<ref name=":13" /> described case reports of breakpoints involving BCL6, CMYC, PAX5, BCL1,
  46 KB (6,495 words) - 13:54, 3 November 2023
• HAEM5:Intravascular large B-cell lymphoma
  ...ging. Radiological findings are often non-specific, but frequently include abnormalities if the central nervous system is imaged using MRI, including hyperintense l ...of three cases of IVLBCL and a literature review, Khoury et al<ref name=":13" /> described case reports of breakpoints involving BCL6, CMYC, PAX5, BCL1,
  55 KB (7,745 words) - 14:29, 13 December 2023
• ACMG technical standards and guidelines: microarray analysis for chromosome abnormalities in neoplastic disorders (2013)
  ...ics technical standards and guidelines: microarray analysis for chromosome abnormalities in neoplastic disorders. ...errations and therapeutic outcomes. Molecular investigation of chromosomal abnormalities identified by standard methods has led to discovery of genes, and gene func
  59 KB (8,449 words) - 19:11, 27 July 2016
• Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray
  ...t7=Nicolas|last8=Jacob|first8=Karine|last9=Gerges|first9=Noha|date=2015-10-13|title=Non-random aneuploidy specifies subgroups of pilocytic astrocytoma an ...gal|first8=S.|last9=Jauch|first9=A.|date=2007-02-15|title=Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression
  103 KB (13,991 words) - 17:05, 20 April 2021
• HAEM4Backup:Plasma Cell Myeloma
  ...8=Kyle|first8=R. A.|last9=Gertz|first9=M. A.|date=2003-02|title=Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma|u ...heavy chain (IgH) translocations and dysregulated oncogenes in the partner chromosome
  73 KB (10,415 words) - 12:41, 3 November 2023
• HAEM4:Plasma Cell Myeloma
  ...8=Kyle|first8=R. A.|last9=Gertz|first9=M. A.|date=2003-02|title=Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma|u ...heavy chain (IgH) translocations and dysregulated oncogenes in the partner chromosome
  73 KB (10,453 words) - 13:51, 3 November 2023
• HAEM5:Plasma cell myeloma / multiple myeloma
  |+Table 4: Cytogenetic abnormalities on clinical course and prognosis in multiple myeloma (adapted from Rajan an |Isolated monosomy 13,
  80 KB (11,414 words) - 14:36, 13 December 2023
• HAEM4Backup:Primary Amyloidosis
  ...noglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains|url=https://linkinghub.elsevier.com/retrieve/pii/S ...ewald|first9=Gordon W.|date=2000|title=FISH Demonstrates Treatment-Related Chromosome Damage in Myeloid but not Plasma Cells in Primary Systemic Amyloidosis|url=
  40 KB (5,557 words) - 12:42, 3 November 2023
• HAEM4:Primary Amyloidosis
  ...noglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains|url=https://linkinghub.elsevier.com/retrieve/pii/S ...ewald|first9=Gordon W.|date=2000|title=FISH Demonstrates Treatment-Related Chromosome Damage in Myeloid but not Plasma Cells in Primary Systemic Amyloidosis|url=
  40 KB (5,593 words) - 16:34, 4 December 2023
• HAEM5:Immunoglobulin-related (AL) amyloidosis
  ...noglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains|url=https://linkinghub.elsevier.com/retrieve/pii/S ...ewald|first9=Gordon W.|date=2000|title=FISH Demonstrates Treatment-Related Chromosome Damage in Myeloid but not Plasma Cells in Primary Systemic Amyloidosis|url=
  48 KB (6,794 words) - 14:27, 13 December 2023

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