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  • ...collaborative effort to document and describe chromosome and other genomic abnormalities in cancer. The Wiki style interface allows for real-time editing and conten ...s]] '''Structural Abnormalities''' '''[[:Category:Structural Abnormalities Chromosome 1|1]]'''
    7 KB (989 words) - 15:57, 6 July 2020
  • ...the leukemia is not classified in the group of AML with recurrent genetic abnormalities due to clinical and prognostic differences. ...distinctive cytogenetic subtype of acute myeloid leukemia. Both of these chromosome rearrangements result in the CBFB-MYH11 gene fusion.
    15 KB (2,049 words) - 16:04, 20 March 2020
  • ...">Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic a ...cal fusions are expressed, the ''RBM15''-''MKL1'' fusion on the derivative chromosome 22 is the candidate oncoprotein because it contains all of the putative fun
    10 KB (1,331 words) - 21:10, 29 December 2019
  • ...ics technical standards and guidelines: microarray analysis for chromosome abnormalities in neoplastic disorders. ...errations and therapeutic outcomes. Molecular investigation of chromosomal abnormalities identified by standard methods has led to discovery of genes, and gene func
    59 KB (8,449 words) - 00:11, 28 July 2016
  • ...the leukemia is not classified in the group of AML with recurrent genetic abnormalities due to clinical and prognostic differences. AML with t(8;21)(q22;q22) is a ...s involving chromosomes 8, 21 and a third chromosome occur; the derivative chromosome 8 in the t(8;21)(q22;q22) and the variant t(8;21;var) carries the RUNX1-RUN
    20 KB (2,839 words) - 19:40, 29 December 2019
  • ...">Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic a ...st8=Gitte|last9=Andersen|first9=Mette Klarskov|date=2003|title=Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all childr
    12 KB (1,744 words) - 19:06, 22 June 2020
  • ...ollaborative project to document and describe chromosome and other genomic abnormalities in cancer. This resource is supported by the [http://www.cancergenomics.org ...e]] '''Structural Abnormalities''' '''[[:Category:Structural Abnormalities Chromosome 1|1]]'''
    7 KB (905 words) - 03:59, 21 November 2017
  • ...">Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic a Accounts for 0.7-1.8% of AML, occurring in both children (median age of 13 years) and adults (median age of 35-44 years)<ref name=":0" />.
    10 KB (1,404 words) - 20:50, 29 December 2019
  • ....gov/pubmed/30350260|journal=Current Hematologic Malignancy Reports|volume=13|issue=6|pages=477–483|doi=10.1007/s11899-018-0489-z|issn=1558-822X|pmid=3 ...et age and shorter median survival<ref name=":5" />. ''RUNX2'', located on chromosome 6p21, is strongly expressed in pDCs and BPDCN cells. The t(6,8) generates m
    17 KB (2,332 words) - 21:04, 6 March 2020
  • ...f>{{Cite journal|last=Manola|first=Kalliopi N.|date=2013|title=Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview|url=https://www.ncbi.n Many cases have other cytogenetic abnormalities in addition to the t(9;22) or a complex karyotype.
    12 KB (1,667 words) - 18:09, 2 January 2020
  • ...osomal abnormalities are detected in approximately 50% of T-ALL/LBL. Other abnormalities include cryptic deletions, often of tumor suppressor genes, and other somat Cytogenetic abnormalities of T-ALL/LBL usually involve rearrangements of the T cell receptor (TCR) ge
    7 KB (1,040 words) - 01:13, 6 May 2020
  • == Structural == * Structural Abnormalities
    10 KB (1,089 words) - 03:30, 21 November 2017
  • ...Number and cn-LOH Abnormalities in AML]] [[Category:Copy Number and cn-LOH Abnormalities in ALL]] [[Category:Cancer Genes A]] [[Category:Cancer Genes B]] [[Category
    14 KB (1,459 words) - 03:32, 21 November 2017
  • ...ion. The t(9:22)(q34.1;q11.2) results in the formation of the Philadelphia chromosome and the chimeric BCR-ABL1 fusion gene. It is worth noting that the fusion g ...there are only a few cases described where acquisition of the Philadelphia chromosome upon disease relapse or transformation of antecedent myelodysplastic syndro
    18 KB (2,580 words) - 00:45, 1 January 2020
  • ...(5;12;7)(p15.1;p13;q32),der(7)t(5;12;7),der(12)del(12)p13p13)t(5;12;7),del(13)(q12q14) was reported in a two year old boy with PEL<ref name=":10" />. !Chromosome Number!!Gain/Loss/Amp/LOH!!Region
    15 KB (2,005 words) - 00:45, 2 January 2020
  • ...icance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia|url=https://www.ncbi.nlm.nih.gov/pubmed/20660833| #Other 3q abnormalities.
    17 KB (2,502 words) - 21:04, 29 December 2019
  • '''Chromothripsis:''' chromosome 11 (70% of supratentorial tumors) |Epigenetic studies suggest range of abnormalities: balanced or unbalanced genomes
    23 KB (3,015 words) - 15:05, 17 November 2018
  • ...mphoblastic leukemias. The majority of cases (>80%) fall within the 44-45 chromosome range. However, beyond this, there are three main groups, that although ra ...edscape Article, Drugs & Diseases, Hematology.</ref>. Hypodiploid ALL with chromosome numbers less than 44 is associated with poor prognosis.
    21 KB (2,885 words) - 21:49, 9 May 2020
  • ...A.|last9=Bräundl|first9=Kathrin|date=2017|title=Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutati ...et al., (2017). B-lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic a
    19 KB (2,674 words) - 01:33, 10 May 2020