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Line 7: − Put your text here+ − − EXAMPLE: Tumor protein p53, ''LFS1, p53, BCC7, TRP53'' − + − Put your text here + − EXAMPLE: chr17:7,571,720-7,590,868 [hg19]+ − EXAMPLE: chr17:7,668,402-7,687,538 [hg38]+ − ==Cancer Category/Type==+ − AML+ − − Put your text here.+ − Put your text here and/or fill in the table with an X where applicable+ + + Line 77:
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no edit summary
==Synonyms==
==Synonyms==
"Core-Binding Factor Beta Subunit"; CBF-Beta; PEBP2B;
==Genomic Location==
==Genomic Location==
'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1
'''Cytoband:''' 16q22.1
'''Genomic Coordinates:'''
'''Genomic Coordinates:'''
chr16:67,029,116-67,101,058(GRCh38/hg38)
chr16:67,063,019-67,134,961(GRCh37/hg19)
==Cancer Category/Type==
'''Acute Myeloid Leukemia (AML);'''
inv(16)(p13;q22) or t(16)(p13;q22), (CBFB andMYH11) also translocation confer a favorable prognosis in their respective diseases (2, 6)
inv(16)(p13;q22) or t(16)(p13;q22), which disrupt CBFB the non-DNA-binding partner of RUNX1 and the MYH11 gene: also translocation confer a favorable prognosis in their respective diseases (2)
==Gene Overview==
==Gene Overview==
The protein encoded by CFBF can bind the protein encoded by RUNX1 to form "Core Binding Factor", a hetero-dimeric transcription factor, which regulates a number of genes responsible for hematopoiesis and osteogenesis (2). The beta subunit is a non-DNA binding regulatory subunit and it allosterically enhances DNA binding by alpha subunit (Runx1 protein). In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
==Common Alteration Types==
==Common Alteration Types==
'''Acute Myeloid Leukemia (AML);'''
inv(16)(p13;q22) or t(16)(p13;q22), (CBFB andMYH11)
{| class="wikitable sortable"
{| class="wikitable sortable"
'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=CBFB ''CBFB'' by GeneCards]''' - general gene information and summaries
'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=CBFB ''CBFB'' by GeneCards]''' - general gene information and summaries
'''[https://www.ncbi.nlm.nih.gov/books/NBK1311/ GeneReviews]''' - information on Li Fraumeni Syndrome
'''[https://www.ncbi.nlm.nih.gov/gene/865 CBFB in NCBI]''' - general gene information and summaries
==References==
==References==