IGH Rearrangements
Immunoglobulin locus rearrangements occur in tumors arising from the B-cell lineage ALL, Lymphoma and Multiple Myeloma.
IGH/K/L partner genes are numerous and include:
- BCL11B
- BACH2
- CCND1
- BCL2
- BANK1
- CCND3
- CCND2
- BCL10
- FGFR3
- CEBPA
- DUX4
- BCL11A
- IRF4
- CEBPB
- BCL2
- MAF
- CEBPD
- BCL3
- MAFB
- CEBPE
- BCL6
- MMSET
- CEBPG
- BCL7A
- MYC
- CRLF2
- BCL8
- EPOR
- CBAFA2T3
- HOXA
- CCND1
- ID4
- CCND2
- IGF2BP1
- CCNE1
- IL3
- CD44
- LCK
- CDK6
- LMO1
- CND3
- LMO2
- FCGR2A
- LYL1
- FCGR2B
- MYC
- FOXP1
- NOTCH1
- GPR34
- OLIG2
- IRF4
- TAL1
- IRF8
- TAL2
- IRTA1
- TCL1
- LHX2
- TLX1
- MALT1
- TLX3
- MUC1
- MYC
- NFKB2
- PAFAH1A2
- PAX5
- RCK
- SPIB
- ZPP36L1